What to know for fantasy: Think the Bears, a three-point favorite, will win this game? Betting nugget: The Dolphins have covered five of the past seven meetings with Buffalo that did not occur in Week 17. What to know for fantasy: No player in the NFL accounted for a greater percentage of his team's Week 1 scrimmage yards than Jamison Crowder (45.3%). The Colts' secondary proved suspect in Week 1, allowing the Seahawks to pass for four touchdowns. Jackson is 0-3 in his career versus the Chiefs, largely due to accuracy issues, failing to complete 55% of his passes in any of those three matchups. They ran a four-receiver set on a league-high 25% of their snaps last week, and despite the Dolphins' struggles against the run in Week 1, the Bills will commit once again to their passing game. More NFL coverage , Bold prediction: Jones and J.J. Watt will each get two sacks. And FPI noticed, dropping them five spots in overall FPI rank to No. Pick NFL winners straight up or against the spread and compete to win more than $14,400 in prizes! -- Alden Gonzalez, Bold prediction: The Chiefs, who intercepted 15 passes in their past six games against the Chargers, will get a couple of picks against Tyrod Taylor. In Week 1, they covered easily, and the under once again cashed. Godwin not worried: Bucs learning life with Brady, 1 p.m. In two games following a 25-point loss under coach Matt Lafleur, Rodgers has thrown four touchdown passes in each. Betting nugget: The Steelers have had just one losing ATS season at home since 2010 (3-5 ATS at home in 2017). Coach Kyle Shanahan manages a running back fantasy factory and will have to work more magic with Raheem Mostert out for the foreseeable future. What to know for fantasy: Playoffs included, wideout Antonio Brown has run more than 25 routes eight times in his Buccaneers career, including last week with 36 routes. See Week 2 rankings. Note: All times eastern. Football Power Index projects a close game, with Florida coming in as the favorites to win with a narrow 54.8 percent chance to beat UK. -- Shelley Smith, Bold prediction: Dak Prescott will not throw for 400 yards. Prime-time Parlay is your FPI-based guide predicting the results of all the biggest games of Week 2. . Both rushed for seven touchdowns in 2019, but they also each scored eight touchdowns (with no interceptions) when passing on the run, according to ESPN Stats & Information research. Stat to know: The Packers' offense was bad in Week 1, but maybe there's a silver lining. Watt done 'tiptoeing' around his training, Jones: Contract will come as sacks pile up, A healthy Murray makes Cardinals a contender, Ryan: Super Bowl loss has 'no bearing' on game vs. Brady, Buccaneers, Bucs RB Jones to start despite Week 1 benching, Patterson -- now clearly a running back -- finds a role in Atlanta's offense. ET | CBS He has thrown for at least three TD passes in four of six games against Miami and has averaged 8.7 yards per attempt in those six games. Transactions Transactions; Prime-time Parlay: Straight-up picks for this week's biggest games. A loss would drop that to a 38 percent chance at the division, and 49 percent at making the playoffs. FPI prediction: SEA, 61.8% (by an average of 4.3 points), Matchup must-reads: Belichick calls Seattle Seahawks QB Wilson underrated Bring your own energy: Carroll's Seahawks prepared for no fans at CenturyLink Did Patriots revamp their playbook for Newton? -- Seth Walder. Read more. 3 receiver? What to know for fantasy: Allen has thrown multiple touchdown tosses nine times in his career, and he is 4-for-4 against the Dolphins and 5-for-25 against the rest of the NFL. ET | CBS What to know for fantasy: Wideout Stefon Diggs had 15.9 fantasy points -- nine catches for 69 yards -- in the Bills' Week 1 loss to Pittsburgh. NFL FPI NFL FPI; . If Darnold sputters, Jets will face complex question: Trevor Lawrence? Matchup rating: 75.4 | Spread: BAL -7 (50), What to watch for: Will Lamar Jackson and Deshaun Watson continue to have success on the run? Let's get into the full Week 2 slate, including a meeting between Patrick Mahomes and Lamar Jackson on Sunday night, a battle between two AFC East rookie QBs and Patrick Peterson's return to Arizona. (He has nine touchdowns over that run.) Quarterback Joe Burrow is looking for the first road win of his career; he is 0-5-1 with a Total QBR of 45 in six career road starts. Scroll down to take a look at the FPI projections for every matchup on the Week 12 college football slate, with games listed in chronological order. FPI prediction: NO, 60% (by an average of 3.7 points), Matchup must-reads: Saints' defense delivering on vow to be team's identity without Brees How McCaffery 'opens up all of the possibilities' of the Panthers' offense Lattimore among key Saints dealing with injuries Reddick: Panthers' D 'put league on notice' with six sacks, 1 p.m. Even that might not be enough to fend off Fields. Matchup rating: 47.1 | Spread: TB -8.5 (47.5), What to watch for: The Bucs fell short in their quest to go toe-to-toe with the Saints last week, but since his first career start in 2001, Tom Brady has a career 48-13 record coming off a loss (.787 win percentage), second only to that of Russell Wilson. On the other side of things, how long will Falcons coach Arthur Smith stick with the run against the league's top-ranked run defense over the past two years? -- Nick Wagoner. -- Mike DiRocco, Game picks from our NFL experts Quarterback Joe Burrow is looking for the first road win of his career; he is 0-5-1 with a Total QBR of 45 in six career road starts. Visit ESPN to view NFL Expert Picks for the current week and season . Read more. What to know for fantasy: 250 passing yards, 25 rushing yards, a passing touchdown and a rushing touchdown. What to know for fantasy: Steelers wideout Chase Claypool's ceiling captures headlines, but after Week 1, he has now failed to score more than 10 fantasy points in five of his past seven games. -- Eric Woodyard. CLE at CIN Sun 6:00PM. -- Michael Rothstein. The embattled former second overall pick led Chicago to a memorable fourth-quarter comeback in Week 1, but not even Trubisky's three touchdown passes in the final 15 minutes could cover up for how inconsistent he played in the opening three quarters at Ford Field. In six career games, Allen is 5-1 against Miami with 1,552 passing yards, 17 touchdowns and just four interceptions. CLE at CIN Sun 6:00PM. What to know for fantasy: Playoffs included, wideout Antonio Brown has run more than 25 routes eight times in his Buccaneers career, including last week with 36 routes. What to know for fantasy: The Cowboys are a three-point underdog, so Prescott managers have their opponent right where they want them. Now we are down to 17; here are the schools that still have a mathematical playoff chance, according to FPI. Jump into a draft >>, With our live draft lobby, you can be drafting a team in minutes. See Week 2 rankings. Stat to know: The Bengals have the NFL's worst road record of 3-20-1 (.146) since 2018. Matchup rating: 64.3 | Spread: LAR -3.5 (48), What to watch for: Aaron Donald vs. Quenton Nelson. Cimini's pick: Patriots 22, Jets 17 See Week 2 rankings. See Week 2 rankings. A Titans win would make them 53 percent favorites to win the division (with a 60 percent chance at making the playoffs), while a loss would drop them to a 23 percent chance at the division and 32 percent chance at the playoffs overall. -- Jeff Dickerson, Bold prediction: The Bengals will have two wide receivers with at least 75 receiving yards, and look for the Cincinnati to attack the right sideline. Young can be moved around but had his best success as a right end against Jason Peters last week. Pick NFL winners straight up or against the spread and compete to win more than $14,400 in prizes! Even if Bradley Chubb doesn't play or is limited, Von Miller will be hard to handle. Teicher's pick: Chiefs 27, Chargers 20 Asked about his mindset if Jackson misses more games because of injury, Huntley . Dickerson's pick: Bears 21, Giants 18 NFL experts predict: Week 6 upset picks, fantasy sleepers, disappointing players, more 2y ESPN NFL Experts Week 6 Love/Hate: Reinvent your fantasy football season with a new format DiRocco's pick: Titans 17, Jaguars 16 Zach Wilson and Mac Jones, coming off encouraging openers, meet for the first time in what should be a long personal rivalry. But the Cowboys are just 1-3 in those four games and know that is not a long-term formula for success. Matchup rating: 37.6 | Spread: GB -11.0 (48), What to watch for: How will the Lions try to defend Aaron Rodgers and the Packers' offense? ET | NBC Read more. -- Mike Wells, Bold prediction: Vikings receiver Adam Thielen will haul in seven catches for 120-plus yards. The inaugural edition of Prime-time Parlay did not hit, as FPI's straight-up prediction of a New York Giants win over the Jacksonville Jaguars was not successful, nor was the pick of the Detroit Lions over the New York Jets (yes, this was wildly incorrect). The Bears put him in the slot throughout that game and let him eat. He has eight 400-yard passing games since 2016, most in the NFL. Matchup rating: 49.6 | Spread: GB -6.5 (49), What to watch for: Can Packers receiver Davante Adams have another big day after his career-high 14-catch performance in Week 1 against the Vikings? Stat to know: The Cowboys are looking to avoid their first 0-2 start since 2010; the only time they have started 0-2 with both games on the road was in 1989. -- Paul Gutierrez. -- Sarah Barshop. What to know for fantasy: From 2017 to 2020, the 49ers ranked fourth in running back fantasy points. 'Don't panic' Tagovailoa already clicking with receiver Waddle, 1 p.m. Read more. What to know for fantasy: Jacksonville running back James Robinson scored at least 10 fantasy points in every game last season as an unknown resource. FPI prediction: NO, 60% (by an average of 3.7 points), Matchup must-reads: Saints' defense delivering on vow to be team's identity without Brees How McCaffery 'opens up all of the possibilities' of the Panthers' offense Lattimore among key Saints dealing with injuries Reddick: Panthers' D 'put league on notice' with six sacks, 1 p.m. The 2004 Colts are the other, as they faced Tom Brady (Super Bowl MVP) and Steve McNair (MVP) to open their year. Read more. He moves around. The second was the 2019 Packers, who won both of their games against Detroit last season on game-ending field goals despite not holding a lead at any point in either game. Trotter's pick: Browns 34, Texans 17 Depth charts for every team 2 pick. Betting nugget: The Saints covered every game last season that went under the total (six), making them the only team in the league to do so. FPI prediction: TB, 78.1% (by an average of 11.2 points). Have the Vikings finally found their No. Triplett's pick: Saints 23, Panthers 19 4:25 p.m. Texas wide receiver DeAndre Hopkins had 287.8 points in 16 games last season. Wilson followed up the 2020 opener with five passing touchdowns in consecutive games. ET | FOX Stat to know: Jameis Winston looks to lead the Saints to their first 2-0 start since 2013. Keim's pick: Cardinals 21, Washington 17 How each performs on Sunday will be a difference-maker for two passing offenses looking to get going after Week 1 losses. ET | FOX Not so fast Adams fires back at Jets' Gregg Williams; not 'bored' in Seahawks debut, Monday, 8:15 p.m. FPI prediction: PIT, 66.8% (by an average of 6.2 points), Matchup must-reads: QB Lock shows his leadership in season-opening loss Steelers' Roethlisberger is sore, but elbow is good after first game After drops, Broncos' Jeudy determined to prove 'failure is growth', 1 p.m. Read more. How will Patriots' Mac Jones handle Cardinals' blitz on MNF? Betting nugget: Philadelphia is 5-0-1 against the spread (ATS) against the Rams since 2006. How Mayfield remade his body after a disappointing 2019 No setback, but Browns rule out OBJ vs. Texans, 1 p.m. In Chicago's final three wins of 2020, David Montgomery averaged 146 total yards per game on his way to 24.6 fantasy points per game. -- Shelley Smith, Bold prediction: Dak Prescott will not throw for 400 yards. The Cowboys received a decent-sized FPI upgrade after handily beating the Giants, whom the model previously had pegged as having the best defense in the NFL. See Week 2 rankings. The sixth-round pick was a relative unknown a week ago, then he set a record for rushing yards (104) by a Niner in his debut, against the Lions. Pryor's pick: Steelers 31, Broncos 16 And if the Broncos keep the Jaguars in difficult down-and-distance situations, Lawrence could have a tough time finding room to work. -- Jake Trotter, Bold prediction: The Browns hold the Texans to fewer than 50 rushing yards. -- Seth Walder, Money line: Bears -180 Rodgers has had just intermittent success against Matt Patricia's Lions, but this is a different Detroit secondary. -- Mike Reiss. Tampa has won five of those games, and AB has found the end zone in all five. In 10 career starts vs Panthers, he has a Total QBR of 40. 3 receiver? -- Jordan Raanan. FPI prediction: NE, 64.8% (by an average of 5.5 points), Matchup must-reads: Will Belichick reduce Harris' workload after fumble? Hensley's pick: Chiefs 27, Ravens 24 Then he was flagged for 30-yard pass interference, which ended up leading to a field goal for the Jaguars. Read more. Sam Bradford's magnificent game against the Saints on Monday Night Football prompted more than a two-point bump in the Vikings' offensive FPI. Betting nugget: San Francisco is 7-21-2 ATS in its past 30 games as a favorite. Louis-Jacques' pick: Bills 31, Dolphins 17 Stat to know: Samuel had a career-high 189 receiving yards in Week 1. Keim's pick: Cardinals 21, Washington 17 Weinfuss' pick: Cardinals 31, Washington 24 FPI prediction: ARI, 68.2% (by an average of 6.8 points) Matchup must-reads: Young, Washington's pass rush 'as advertised' in promising start. After Bills' sloppy mistakes led to season-opening loss, what's the message? People are talking about the NFL's offensive explosion and Bills fans are probably thinking, "huh?" Buffalo's offense -- under Josh Allen, Nathan Peterman or Derek Anderson, it doesn't matter -- is hard to . Early NFL predictions and picks are from ESPN's Football Power Index (FPI): 49ers: 40.2% to win; Broncos: 59.3% to win; Even while playing at home, Russell Wilson and the Denver Broncos are not considered big favorites in this matchup. NFL Expert Picks - Week 14 . What to know for fantasy: Saints wide receiver Emmanuel Sanders led the league with four red zone targets in Week 1 and figures to stay busy with Thomas' role now potentially up for grabs -- if he is healthy enough to play himself. The Eagles should be a bit better slowing the run than Detroit was, but this is a defense that looks vulnerable at the second level, which could make them susceptible to Mitchell's one-cut-and-go ability. Dickerson's pick: Bears 21, Bengals 20 In April, they finally became teammates when the Eagles acquired Brown from the Tennessee Titans for the 18th and 101st overall picks -- a move Hurts championed and helped get to the finish line. What to know for fantasy: Chiefs wideout Tyreek Hill has 310.6 fantasy points over his past 12 games (playoffs included). The Jaguars are making Henry their top priority -- they might get hurt by the pass game, but they're not going to let Henry beat them again. FPI prediction: PIT, 64.5% (by an average of 5.4 points), Matchup must-reads: Raiders' Crosby not resting on Monday night laurels heading to Pittsburgh Steelers' Watt caps 'heck of a week' by helping lead upset win over Bills Second-half utilization of wide receivers allows Carr, Raiders to find rhythm Carr rallies Raiders past Ravens in wild OT win: 'Hope this is a sign of things to come', 1 p.m. Demovsky's pick: Packers 23, Lions 17 -- Rob Demovsky, Bold prediction: Green Bay quarterback Aaron Rodgers throws four more touchdowns this week against Detroit. The reason is that as much as Green Bay's defense performed above expectation, its offense fell far short of what the model anticipated. KC -4. Read more. -- Alaina Getzenberg. -- Adam Teicher. Can he improve while trying to contain Minnesota's passing attack? Scroll down to take a look at the FPI projections for every matchup on the Week 2 college football slate, with games listed in chronological order. Read more. ET, NBC). In Chicago's final three wins of 2020, David Montgomery averaged 146 total yards per game on his way to 24.6 fantasy points per game. ET | FOX Raiders ecstatic to finally open luxurious 'Death Star' Allegiant Stadium Saints lock up LB Davis with 3-year extension, source says After struggling, Raiders' defense shows up when it matters most, Guide to every Week 2 NFL game: Picks, matchup nuggets, more, Huntley hurt as Ravens again lose a starting QB, Steelers' Pickett put in concussion protocol in loss, Jets star DT Williams exits loss with calf injury, Bengals win despite missing Boyd (finger), Higgins, Sources: Saints, coaches, Jordan fined $500K+, Tucker becomes Ravens' career scoring leader, Source: James out for banged-up Bolts vs. Fins, Patrick Mahomes' unreal no-look toss leads to 56-yard touchdown by Jerick McKinnon, NFL Week 14 takeaways: Lions roll, Eagles overpower Giants, Dallas avoids mega upset, Lions first-rounder Jameson Williams scores 41-yard TD on first NFL catch, Tom Brady and Patrick Mahomes show out; more notable NFL Week 14 arrivals. FPI prediction: KC, 71.0% (by an average of 7.9 points), Matchup must-reads: Edwards-Helaire leads solid rookie class for Chiefs SoFi Stadium videoboard: 'Eighth wonder of the world' targets GenZ Mahomes praised for checkdowns in opener Opportunistic defense leads Chargers to narrow win over Bengals, 8:20 p.m. Most noticeably, FPI dropped New England's defensive rank from second all the way to 16th. Unlike the Titans, Minnesota will attempt to help its tackles against Jones, but it won't be enough. This is a new feel for the Patriots-Jets series, which was dominated by a veteran quarterback (Tom Brady) for two decades. NFL Expert Picks - Week 14. Baby's pick: Bengals 28, Bears 24 Dickerson's pick: Bears 21, Bengals 20 FPI prediction: CHI, 54.2% (by an average of 1.6 points) Matchup must-reads: How Burrow's expectations for himself, Bengals are creating success. If Kansas City wins, it's an early lead and a great win. ET. -- Paul Gutierrez, Relive the NFL's greatest games, original series and more. Stat to know: The past four meetings between these teams were decided by exactly three points. Everything you want to know is here in one spot to help you get ready for a loaded weekend of NFL football. What to know for fantasy: The longest active streak of games with 75-plus receiving yards belongs to Calvin Ridley (five straight). New Orleans' secondary will be tested by Carolina's dynamic receivers, which will be a key to this matchup. Irrelevant' to rookie starting QB: The twists and turns of Brock Purdy's journey to the 49ers. Mahomes has an eight-game winning streak in prime-time contests, the longest active streak of any quarterback. Betting nugget: Baker Mayfield is just 4-8 ATS over his past 12 starts. But the Ravens have never given up more than 30 points in each of their first two games of a season. Davenport's pick: Titans 20, Jaguars 14 FPI prediction: KC, 55.7% (by an average of 2.1 points), Matchup must-reads: A promise to his father: Why Orlando Brown left the Ravens for the Chiefs Ravens promote veteran RB Freeman to active roster Chiefs, Mahomes know it can't be just Hill and Kelce Jackson says he's not dwelling on past losses as Ravens prepare to face Mahomes, Chiefs, Monday, 8:15 p.m. What to know for fantasy: Corey Davis was WR16 for an extended stretch last season (Weeks 8 to 15), and he showed out last week with 26.7 points against the Panthers. We'll learn a lot more about that defense when it takes on Drew Brees and the seventh-best offense in New Orleans. Gutierrez's pick: Steelers 31, Raiders 23 And with Russell Wilson putting on a four-touchdown performance in Week 1, it is entirely possible that Titans streak continues. Visit ESPN to view NFL Expert Picks for the current week and season. 4y ESPN.com. "You can't scheme for him on every play because he's not at the same spot every play. The Bucs also will be without starting cornerback Sean Murphy-Bunting. -- Lindsey Thiry. Betting nugget: Jimmy Garoppolo is 8-4 against the spread in regular-season road starts since 2019. He showed in Week 1 that he has made great strides as a passer, but let's not forget he's among the league's most dangerous playmakers when scrambling. Those plays are always there for him against a Ravens team that blitzes a lot but leaves itself vulnerable to big throws. Dickerson's pick: Bears 21, Bengals 20 Falcons' Jones 2nd-fastest WR to record 800 catches Cowboys' Elliott shows off 'Feed Me' tattoo on stomach Sources: Cowboys' Lee had surgery, out until mid-October, 1 p.m. Can Giants' Slayton continue to produce like a No. 4y ESPN.com. Round 1: Kiper | McShay | NFL Nation Demovsky's pick: Packers 23, Lions 17 ET | CBS Taylor would probably love nothing more than to show Mayfield another thing or two on Sunday. -- Mike Wells, Bold prediction: Quarterback Matthew Stafford will throw for more than 300 yards and four touchdown passes in a dominant offensive performance. Irrelevant' to rookie starting QB: The twists and turns of Brock Purdy's journey to the 49ers. Not so fast, Adams fires back at Jets' Gregg Williams; not 'bored' in Seahawks debut, Sources: Saints expect WR Thomas to miss MNF, Raiders ecstatic to finally open luxurious 'Death Star' Allegiant Stadium, Saints lock up LB Davis with 3-year extension, source says, After struggling, Raiders' defense shows up when it matters most, Do Not Sell or Share My Personal Information. Read more. Stat to know: Brady has a career record of 8-0 against the Falcons -- including a win in Super Bowl LI. He had zero TD passes on 62 attempts before his season ended in 2019. Stat to know: Murray threw for a career-high four touchdown passes in Week 1 versus the Titans, with three of those coming on third down. What the Lions do -- and how well they do it -- might help determine what kind of coverages Rodgers sees throughout the season. FPI projection: Jaguars win by 0.2 points, If you're going to face Tom Brady, it's best to do it with the defense that kept opposing quarterbacks to the lowest Total QBR in the league last season. NFL Expert Picks - Week 14. But we have another loaded slate of games . Vikings run out of time to see new reality Colts lose Mack for season with torn Achilles Colts sad for Mack, excited about Taylor Rivers brings turnover problems to Colts in Week 1, 1 p.m. ET | Fox In two games following a 25-point loss under coach Matt Lafleur, Rodgers has thrown four touchdown passes in each. Will Belichick reduce Harris' workload after fumble? Stat to know: Since last season's Week 2 game at Miami, Allen's QBR is 78, which ranks third behind Aaron Rodgers and Patrick Mahomes. And if the Broncos keep the Jaguars in difficult down-and-distance situations, Lawrence could have a tough time finding room to work. FPI prediction: LAR, 55.5% (by an average of 2.1 points), Matchup must-reads: Ramsey leads entertaining cast of characters in Rams' secondary Wentz won't have a chance if Colts' O-line doesn't protect him better Stafford throws for 3 TDs as his big-play ability is on display in winning Rams debut, 1 p.m. What to know for fantasy: Rodgers had no touchdown passes and two interceptions Week 1 at the Saints. MIN-ARI | ATL-TB | DAL-LAC See Week 2 rankings. If Darnold sputters, Jets will face complex question: Trevor Lawrence? That gives Kentucky a 45.2 percent shot to take down the . The Giants apparently haven't fixed that problem. -- Jenna Laine, Bold prediction: Matt Ryan will have a 300-yard, three-touchdown day against Tampa Bay -- but it still results in a loss. Jackson is 0-3 in his career versus the Chiefs, largely due to accuracy issues, failing to complete 55% of his passes in any of those three matchups. Demovsky's pick: Packers 31, Lions 25 The Falcons will find a way to get on track offensively; Ryan had 621 yards and five touchdowns in two games against the Buccaneers last season. Watt done 'tiptoeing' around his training Jones: Contract will come as sacks pile up A healthy Murray makes Cardinals a contender, 4:05 p.m. Read more. He has never had back-to-back games with zero passing TDs as a starter. Prime-time Parlay: Straight-up picks for this week's biggest games. On top of playing at an already difficult venue in Arrowhead, the Eagles are at a rest disadvantage, as Kansas City played their Week 1 matchup on Thursday. Stat to know: The Browns did not lose consecutive games last season. More NFL coverage , Bold prediction: The Panthers will sack Brady at least five times and pull off an upset. TEN-SEA | KC-BAL | DET-GB, 1 p.m. Jump to a matchup: Read more. Our NFL Nation reporters bring us the keys to every game, a bold prediction for each matchup and final score picks. -- Jamison Hensley. How will Patriots' Mac Jones handle Cardinals' blitz on MNF? -- Lindsey Thiry. Miami's defense, especially the secondary, could cause issues for the Bills, but the Dolphins won't be able to replicate the Steelers' pass rush. ET | ESPN Last week, a tough win in Tennessee. Prime-time Parlay is your FPI-based guide predicting the results of all the biggest games of Week 3. CAR-TB | BUF-MIA | JAX-TEN -- Rob Demovsky, Bold prediction: The Lions will pull off their first upset of the Dan Campbell and Jared Goff era. Those plays are always there for him against a Ravens team that blitzes a lot but leaves itself vulnerable to big throws. The Raiders' and Steelers' offensive lines are works in progress, but Crosby is coming off AFC Defensive Player of the Week honors, while the ink on Watt's four-year, $112 million extension is still wet. The Bears rookie quarterback played five snaps and scored a rushing touchdown in Chicago's Week 1 loss to the Rams. ET | Fox How good is that? -- Alaina Getzenberg. Week 14 inactives: Who's in and who's out? -- Jeff Legwold. Weinfuss' pick: Cardinals 34, Vikings 17 'Don't panic', Tagovailoa already clicking with receiver Waddle, Ramsey leads entertaining cast of characters in Rams' secondary, Wentz won't have a chance if Colts' O-line doesn't protect him better, Stafford throws for 3 TDs as his big-play ability is on display in winning Rams debut, Saints' defense delivering on vow to be team's identity without Brees, How McCaffery 'opens up all of the possibilities' of the Panthers' offense, Lattimore among key Saints dealing with injuries, Reddick: Panthers' D 'put league on notice' with six sacks, Without Mostert, Lance could be eventual key to 49ers' run game, Hurts' statement game offers Eagles hope: 'He's the leader', Losing Verrett would make 49ers' rise substantially more difficult, Hurts' jersey sales surge 500% after Eagles' Week 1 win, Raiders' Crosby not resting on Monday night laurels heading to Pittsburgh, Steelers' Watt caps 'heck of a week' by helping lead upset win over Bills, Second-half utilization of wide receivers allows Carr, Raiders to find rhythm, Carr rallies Raiders past Ravens in wild OT win: 'Hope this is a sign of things to come', Texans show blueprint for 2021 success, but not everything is perfect. ET | FOX FPI prediction: ARI, 68.2% (by an average of 6.8 points), Matchup must-reads: Young, Washington's pass rush 'as advertised' in promising start Hopkins has championship aspirations with Murray as his QB, 4:25 p.m. Baker Mayfield, who took over for Taylor as a rookie during the 2018 season, praised Taylor for his leadership and mentorship this week. ESPN researcher Kyle Soppe hands out helpful fantasy football and betting nuggets, as well. Betting nugget: The Lions have covered in six straight games against the Packers. Chicago surrendered four completions for 138 yards and a touchdown down the right sideline against the Rams, according to NFL Next Gen Stats. Betting nugget: Chicago is 1-6 ATS in its past seven games as a favorite. Los Angeles coach Brandon Staley has said the team needs to work Ekeler into the passing game. -- Brady Henderson, Bold prediction: Undrafted rookie running back J.J. Taylor will make a play that leads the national television audience to take notice. 2d ESPN . Will Belichick reduce Harris' workload after fumble? The Jags have allowed at least 20 points in each game of the skid. If he reaches 100 yards against the Eagles, he would have the most receiving yards in the first two games of the season by a 49ers player in team history. Stat to know: The Bengals have the NFL's worst road record of 3-20-1 (.146) since 2018. MIN-ARI | ATL-TB | DAL-LAC Scouting reports | More draft coverage, Bold prediction: Henry doesn't hit 100 yards rushing. This rematch of last year's NFC Championship Game features two teams that FPI considers to still be extremely close in strength. How Mayfield remade his body after a disappointing 2019, No setback, but Browns rule out OBJ vs. Texans. In losing five of six games to the Chiefs since Anthony Lynn took over as head coach, the Chargers' offense has committed 17 turnovers, and their defense has generated only two of them. He has 16 such plays in three career starts against the Ravens, who come into this game with a depleted secondary. We have to be able to make some in-game adjustments." -- Tim McManus, Bold prediction: 49ers running back Elijah Mitchell will go over 100 rushing yards for the second straight week to begin his rookie season. Let's get into the full Week 2 slate, including a meeting between Patrick Mahomes and Lamar Jackson on Sunday night, a battle between two AFC East rookie QBs and Patrick Peterson's return to Arizona. Gutierrez's pick: Steelers 31, Raiders 23 Do Not Sell or Share My Personal Information. We should keep an eye on whether that success continues against a revamped Dolphins defense which now includes former Bills edge rusher Shaq Lawson but still gave up 217 rushing yards last week to the Patriots -- including 75 yards to Cam Newton. Two weeks ago, a tough win over division-rival Pittsburgh. Why should they? Jets place RB Bell on IR with hamstring injury, sign Ballage, 1 p.m. ET | CBS Matchup rating: 73.5 | Spread: KC -8 (47.5), What to watch for: Keep an eye on the turnover margin. Stat to know: Stafford hasn't started a season 2-0 since 2017. See Week 2 rankings. Matchup rating: 38 | Spread: ARI -7 (46.5), What to watch for: The matchup to watch will be Cardinals quarterback Kyler Murray vs. Washington edge rusher Chase Young. Our NFL Nation reporters bring us the biggest keys to every game, a bold prediction for each matchup and, of course, final score picks. And while the Chargers have won the past three games versus Dallas, they are 0-3 against Mike McCarthy-led teams. ET | ESPN Even that might not be enough to fend off Fields. Denver won't load up on the blitzes against Jaguars rookie quarterback Trevor Lawrence, and while the Broncos certainly see Lawrence's obvious talents, he will face of a variety of four-man pressures backed by a variety of coverage looks from Vic Fangio's defense. Newton's pick: Saints 30, Panthers 17 After a limited opening. Matchup rating: 38.7 | Spread: NE -6.0 (43), What to watch for: Here come the rookie quarterbacks. LV at LAR Fri 1:15AM. The Jags have allowed at least 20 points in each game of the skid. Baltimore's defense looked vulnerable Monday night, when it allowed 33 points in Las Vegas. Barshop's pick: Browns 27, Texans 17 Matchup rating: 84.8 | Spread: KC -3.5 (54.5), What to watch for: Patrick Mahomes has diced up the Ravens' defense in three meetings, with the Chiefs averaging 31.3 points per game. ESPN's matchup quality metric, which utilizes ESPN's Football Power Index to rank games on a 1-100 scale based on the quality of teams and projected closeness of the final score, tells us the top games of Week 2. Whether he suits up will be something to keep an eye on. See Week 2 rankings. ESPN's FPI predicts every Week 4 game. Getzenberg's pick: Bills 31, Dolphins 24 Maybe he throws for just 399 yards instead. Los Angeles, on the other hand, enters with a 56% chance to make the playoffs. Stat to know: Jacksonville, dating back to last season, is on the verge of losing 17 straight games, which would be tied for the fourth-longest losing streak since the merger in 1970. Can he rebound from his one-catch performance? Clutch keep-away drive allows Chargers rare drama-free victory Cowboys' McCarthy: 'A challenge' when O-line is in flux again, 4:25 p.m. FPI gives the Roadrunners a 60.3 . What are the five must-watch NFL games this week? FPI is high on Prescott, part of the reason it likes Dallas more than Vegas. Matchup quality: 70 out of 100 Taking out Taylor's four carries for 40 yards, Houston ran for 120 yards on 37 carries in Week 1 (3.2 yards per carry) against Jacksonville. See Week 2 rankings. Teicher's pick: Chiefs 30, Ravens 20 And while the Chargers have won the past three games versus Dallas, they are 0-3 against Mike McCarthy-led teams. Stat to know: Both of Brady's interceptions last week came when throwing within 2.5 seconds of the snap, per NFL Next Gen Stats. Visit ESPN to view NFL Expert Picks for the current week and season . Matchup quality: 65 out of 100 Huntley was 8-for-8 for 50 yards on the final drive and scored on a 2-yard touchdown run with 28 seconds remaining. ET | CBS See Week 2 rankings. While this matchup won't determine the game, it'll definitely have an impact and will be fun to watch. Matchup rating: 45.8 | Spread: CLE -12.5 (48), What to watch for: How will Houston quarterback Tyrod Taylor perform in his return to Cleveland? Read more. 'Don't panic', Tagovailoa already clicking with receiver Waddle, Ramsey leads entertaining cast of characters in Rams' secondary, Wentz won't have a chance if Colts' O-line doesn't protect him better, Stafford throws for 3 TDs as his big-play ability is on display in winning Rams debut, Saints' defense delivering on vow to be team's identity without Brees, How McCaffery 'opens up all of the possibilities' of the Panthers' offense, Lattimore among key Saints dealing with injuries, Reddick: Panthers' D 'put league on notice' with six sacks, Without Mostert, Lance could be eventual key to 49ers' run game, Hurts' statement game offers Eagles hope: 'He's the leader', Losing Verrett would make 49ers' rise substantially more difficult, Hurts' jersey sales surge 500% after Eagles' Week 1 win, Raiders' Crosby not resting on Monday night laurels heading to Pittsburgh, Steelers' Watt caps 'heck of a week' by helping lead upset win over Bills, Second-half utilization of wide receivers allows Carr, Raiders to find rhythm, Carr rallies Raiders past Ravens in wild OT win: 'Hope this is a sign of things to come', Texans show blueprint for 2021 success, but not everything is perfect. The 2021 college football season is officially in full swing, and the first three weeks have not been lacking for excitement . 8. Transactions | Injuries Betting nugget: Unders are 10-2-1 in Arizona games played in the first month of the season since 2018. Eagles corner Darius Slay likened 49ers receiver Deebo Samuel to a faster Anquan Boldin and said the key to success against such a dynamic offense is to read its keys and stay disciplined. FPI win projection: Steelers, 64 percent. Matchup rating: 53 | Spread: SF -6.5 (41), What to watch for: It's a battle of two relatively inexperienced quarterbacks -- the 49ers' Jimmy Garoppolo and the Jets' Sam Darnold (27 career starts each). Thiry's pick: Rams 24, Eagles 21 Matchup rating: 32.5 | Spread: CHI -5.5 (42), What to watch for: The focus is squarely on Bears quarterback Mitchell Trubisky. Stat to know: The Packers' offense was bad in Week 1, but maybe there's a silver lining. But it's hard to see the game playing out the same way, and if the Texans are playing from behind for most of the tilt, it's easy to see how Cleveland's front seven dominates Houston's backs. See Week 2 rankings. On the flipside, the Texans won consecutive games only once last season, and they have not started a season 2-0 since 2016. Huntley hurt as Ravens again lose a starting QB, Steelers' Pickett put in concussion protocol in loss, Jets star DT Williams exits loss with calf injury, Bengals win despite missing Boyd (finger), Higgins, Sources: Saints, coaches, Jordan fined $500K+, Tucker becomes Ravens' career scoring leader, Source: James out for banged-up Bolts vs. Fins, Patrick Mahomes' unreal no-look toss leads to 56-yard touchdown by Jerick McKinnon, NFL Week 14 takeaways: Lions roll, Eagles overpower Giants, Dallas avoids mega upset, Lions first-rounder Jameson Williams scores 41-yard TD on first NFL catch, Tom Brady and Patrick Mahomes show out; more notable NFL Week 14 arrivals. Offensive coordinator Brian Schottenheimer has said matchups will factor into how much the Seahawks throw early, and the matchup this week includes the league's reigning Defensive Player of the Year, cornerback Stephon Gilmore. Julio Jones and Davante Adams are chasing him, as they each have four straight. Carr has thrown at least one passing touchdown with zero interceptions in five straight games, the second-longest active streak in the NFL and tied for the longest streak of his career. Clutch keep-away drive allows Chargers rare drama-free victory Cowboys' McCarthy: 'A challenge' when O-line is in flux again, 4:25 p.m. Texas wide receiver DeAndre Hopkins had 287.8 points in 16 games last season. Triplett's pick: Saints 23, Panthers 19 -- Jeff Legwold. Jump into a draft >>, Bold prediction: Cornerback Bradley Roby will have an interception in his Saints debut after arriving in a trade from Houston last week. For more from ESPN Analytics, visit the ESPN Analytics Index. And keep an eye on outside linebackers Melvin Ingram III, T.J. Watt and Alex Highsmith trying to minimize tight end Darren Waller -- a player who certainly has their attention after 19 targets a week ago. Watch for Rams coach Sean McVay to dial up the passing game once again on Sunday. (Game times are Sunday unless otherwise noted. What to know for fantasy: Washington posted a sack on 16% of Philadelphia dropbacks last week, the highest rate in the league and better than any performance it had last season. . Betting nugget: Teddy Bridgewater is 22-3 ATS on the road as a starter, but one of his rare losses against the spread came in Week 2 of last season at Tampa Bay, when he played for the Panthers. Vegas isn't far behind, since it made Baltimore road favorites. FPI downgraded the Patriots by three whole points in a single week after they got beat up by the Chiefs. Oh, to be a young pass-rusher in this game. Graziano and Fowler predict Week 2 surprises, fantasy sleepers, more: Are the Bengals legit? In his past three losses, Prescott is averaging 57.7 passes and 30.7 fantasy points per game. If he gets at least 317 passing yards against the Colts, he will have the most passing yards through the first two games of a season in his career. He gave up a 22-yard touchdown when he was caught peeking in the backfield, expecting a run. Seattle's Russell Wilson threw four touchdown passes against the Falcons last week, so you should see some course correction in turns of pass defense, which means Elliott is in for a big day. See Week 2 rankings. Cutting down on those mistakes against Atlanta will be key. The Chiefs and Chargers will battle for the AFC West all year. How well Darnold handles duress will be key for Carolina keeping pace. TEN-SEA | KC-BAL | DET-GB, 1 p.m. In Week 1, they covered easily, and the under once again cashed. Fantasy. Cutting down on those mistakes against Atlanta will be key. See Week 2 rankings. Read more . NFL FPI NFL FPI; . Gonzalez's pick: Chiefs 31, Chargers 24 Interestingly, the model slightly downgraded the Packers even after they beat a tough opponent in the Seahawks. In 10 career starts vs Panthers, he has a Total QBR of 40. Stat to know: Per the Elias Sports Bureau, the 2020 Texans are the second team in NFL history to face the reigning MVP and Super Bowl MVP in each of their first two games of a season (they faced Patrick Mahomes in Week 1). There have been only two series in NFL history featuring five straight games decided by exactly three points. ESPN Fantasy's Kyle Soppe and ESPN Chalk's Dave Bearman hand out helpful nuggets as well. Additionally, ESPN Stats & Information research provides a stat to know, and the Football Power Index (FPI) goes inside the numbers with a matchup rating (on a scale of 1 to 100) and a game projection. Stat to know: Chiefs quarterback Patrick Mahomes is 8-0 with an 89 Total QBR and 26 passing touchdowns in the month of September, all the best in the NFL since the start of the 2018 season. Also, keep an eye on Pittsburgh's Ben Roethlisberger; he needs three passing touchdowns to become the eighth NFL player with 400 passing touchdowns. HOU at DAL Sun 6:00PM. Veteran starter Andy Dalton -- formerly of the Bengals -- will need to play exceptionally well to hold onto the job. The Raiders' and Steelers' offensive lines are works in progress, but Crosby is coming off AFC Defensive Player of the Week honors, while the ink on Watt's four-year, $112 million extension is still wet. Mahomes has an eight-game winning streak in prime-time contests, the longest active streak of any quarterback. Raanan's pick: Bears 22, Giants 21 Prime-time Parlay is your FPI-based guide that predicts the results of all the biggest NFL games of Week 17. . It's the first time in the 62-year history of the rivalry that rookie QBs are starting against each other. Matchup rating: 34.3 | Spread: DEN -6.0 (45.5), What to watch for: The Jaguars' offensive tackles struggled last season, with Cam Robinson and Jawaan Taylor combining to allow 27 sacks, per ESPN Stats & Information research. Matchup rating: 67.3 | Spread: BUF -3.0 (47.5), What to watch for: The Dolphins have yet to solve Josh Allen over the course of his career. Week 14's Sunday slate brings us an abundance of intriguing NFL matchups, including the Cincinnati Bengals (-6, 46.5) hosting the division-rival Cleveland Browns, the New York Jets going for a season sweep of the Buffalo Bills (-9.5, 43), the Philadelphia Eagles (-7, 45) visiting the New York Giants, and the San Francisco 49ers (-3.5, 37.5 . Hurts' jersey sales surge 500% after Eagles' Week 1 win, 1 p.m. FPI prediction: KC, 55.7% (by an average of 2.1 points), Matchup must-reads: A promise to his father: Why Orlando Brown left the Ravens for the Chiefs Ravens promote veteran RB Freeman to active roster Chiefs, Mahomes know it can't be just Hill and Kelce Jackson says he's not dwelling on past losses as Ravens prepare to face Mahomes, Chiefs, Monday, 8:15 p.m. The Week 2 NFL schedule for the 2021 season is stacked with great matchups, and we've got you covered with what you need to know heading into the weekend. Irrelevant' to rookie starting QB: The twists and turns of Brock Purdy's journey to the 49ers. -- Jamison Hensley, Bold prediction: Mahomes will complete six throws of at least 20 yards. Stat to know: Stafford hasn't started a season 2-0 since 2017. ET | FOX Irrelevant' to rookie starting QB: The twists and turns of Brock Purdy's journey to the 49ers. Matchup rating: 49.8 | Spread: PIT -6.0 (47), What to watch for: The Steelers confused Josh Allen and the Bills' offense with their defensive versatility, moving safety Minkah Fitzpatrick all around the field. Coach Kyle Shanahan manages a running back fantasy factory and will have to work more magic with Raheem Mostert out for the foreseeable future. -- Brooke Pryor, Everything you need this week: PickCenter | ESPN Chalk Stat to know: The Dolphins had 87 rushing yards in Week 1, and they had 13 games with fewer than 100 rushing yards last season (tied for the most in the NFL with the Jets). Stat to know: The Titans have allowed more than 35 points in their past three regular-season games. BUF-MIA | LAR-IND | NO-CAR Matchup quality: 72 out of 100 Read more. Betting nugget: The Steelers have had just one losing ATS season at home since 2010 (3-5 ATS at home in 2017). See Week 2 rankings. Betting nugget: The Chargers covered their final two home games of 2020 after failing to cover seven of their previous nine games at their place. Read more. The Chiefs have won 10 straight games overall (including playoffs), the second-longest streak in franchise history (11 straight in 2015 season). FPI win projection: Falcons, 58 percent. Laine's pick: Buccaneers 28, Panthers 21 Betting nugget: Atlanta is 4-0 ATS in its past four road games. Matchup rating: 34.3 | Spread: DEN -6.0 (45.5), What to watch for: The Jaguars' offensive tackles struggled last season, with Cam Robinson and Jawaan Taylor combining to allow 27 sacks, per ESPN Stats & Information research. And they might need to do it again, with top CB Marshon Lattimore now dealing with a thumb injury. Stat to know: Brady has a career record of 8-0 against the Falcons -- including a win in Super Bowl LI. SF-PHI | LV-PIT | HOU-CLE They strayed from their usual establish-the-run M.O. Matchup rating: 50.1 | Spread: IND -3 (48.5), What to watch for: Colts cornerback Xavier Rhodes faces his former team; the Vikings released him in the offseason after seven seasons with the franchise. ET | FOX -- Todd Archer. Matchup rating: 73.4 | Spread: SEA -4 (44.5), What to watch for: Will the Seahawks continue to let Russell Wilson cook? Stat to know: The past four meetings between these teams were decided by exactly three points. Matchup rating: 50.6 | Spread: TB -12.5 (52), What to watch for: It's rare that a team manages to come away with a victory being minus-three in the turnover margin, but the Buccaneers did that against the Cowboys in Week 1. And they might need to do it again, with top CB Marshon Lattimore now dealing with a thumb injury. Its corners are banged up -- Desmond Trufant and Darryl Roberts both missed practices this week -- and rookie Jeff Okudah might be making his debut. Teicher's pick: Chiefs 30, Ravens 20 Straight up picks -- but you gotta hit all five. What will Fields do for an encore? Matchup rating: 32.5 | Spread: CHI -2.5 (45), What to watch for: Justin Fields is always the center of attention. Even still, it's no surprise that this showdown pits what FPI considers to be the second-best offense (Atlanta) against the sixth-best offense (Green Bay). The Lions played man coverage on 82% of their defense snaps in Week 1, the highest rate of any team on opening weekend. -- Seth Walder, Money line: Cowboys -150 In six career games, Allen is 5-1 against Miami with 1,552 passing yards, 17 touchdowns and just four interceptions. Baltimore's defense looked vulnerable Monday night, when it allowed 33 points in Las Vegas. -- David Newton. Opening loss to Texans shows pass rush still a problem for Jaguars Broncos place CB Darby, WR Jeudy on IR Bridgewater makes the first impression Broncos hoped to see, 1 p.m. What to know for fantasy: Wideout Stefon Diggs had 15.9 fantasy points -- nine catches for 69 yards -- in the Bills' Week 1 loss to Pittsburgh. -- Jeff Dickerson, Bold prediction: Bears wide receiver Allen Robinson tops 150 yards receiving. See Week 2 rankings. Philadelphia's defense did not allow a single pass play of 20 or more yards in Week 1 against the Falcons, while the Niners' offense was third in explosive pass plays against the Lions with five. -- Sarah Barshop, Bold prediction: Baltimore's Jackson will rush for at least 100 yards. -- Turron Davenport, All 259 picks | Every team's class He hasn't hit the century mark since Week 13 of the 2018 season, but Gurley does have two 100-yard games in three career meetings with the Cowboys, and the Falcons need to stick with the run. Football Power Index rankings Click on each game for the game preview and CFN Prediction. Young, Washington's pass rush 'as advertised' in promising start, Hopkins has championship aspirations with Murray as his QB, Three ways Jackson is better than his MVP season, Texans must quickly figure out what went wrong, All virus tests negative from Texans' opener, Texans squander chance to show they can thrive without Hopkins, Edwards-Helaire leads solid rookie class for Chiefs, Opportunistic defense leads Chargers to narrow win over Bengals, Bring your own energy: Carroll's Seahawks prepared for no fans at CenturyLink, Did Patriots revamp their playbook for Newton? Opening loss to Texans shows pass rush still a problem for Jaguars Broncos place CB Darby, WR Jeudy on IR Bridgewater makes the first impression Broncos hoped to see, 1 p.m. But the Ravens have never given up more than 30 points in each of their first two games of a season. Pryor's pick: Steelers 24, Raiders 17 And how quickly can a Panthers defense that started four rookies last Sunday make progress in Week 2? Read more. -- Josh Weinfuss, Herbert makes case to get paid His 3.96 yards per rush since Week 7 of last season is the 10th-lowest average in the NFL among 32 players with at least 100 rushes in that span. FPI prediction: CLE, 79.3% (by an average of 11.8 points), Matchup must-reads: Texans show blueprint for 2021 success, but not everything is perfect What did QBs Taylor, Mayfield get out of their year together in Cleveland? SF-PHI | LV-PIT | HOU-CLE It's a showdown between two of the best young players in the NFL, last year's No. Stat to know: Jacksonville, dating back to last season, is on the verge of losing 17 straight games, which would be tied for the fourth-longest losing streak since the merger in 1970. Stat to know: Since last season's Week 2 game at Miami, Allen's QBR is 78, which ranks third behind Aaron Rodgers and Patrick Mahomes.Allen also has thrown more touchdown passes in 16 starts (36) than he did in 28 starts (32) before that game. Power shift in NFC North? Matchup rating: 64.3 | Spread: LAR -3.5 (48), What to watch for: Aaron Donald vs. Quenton Nelson. ESPN + Continue reading this article and more from top writers, for only $9.99/mo. NE-NYJ | DEN-JAX | CIN-CHI On the other side, the Cowboys need a big day from their offense to avoid an 0-2 start. Betting nugget: Jimmy Garoppolo is 8-4 against the spread in regular-season road starts since 2019. (He scored 13 times in his first 24 games with the Browns.) -- Rich Cimini, Bold prediction: The Patriots will make running back J.J. Taylor active as a result of rookie Rhamondre Stevenson's struggles in the opener, and Taylor's presence as a complement to Damien Harris and James White will be key against a Jets defense that blitzed 41.7% of the time in the opening week -- the fifth-highest total in the NFL. -- Josh Weinfuss, Everything you need this week: Zach Wilson and Mac Jones, coming off encouraging openers, meet for the first time in what should be a long personal rivalry. -- Jeff Dickerson, Bold prediction: The Bengals will have two wide receivers with at least 75 receiving yards, and look for the Cincinnati to attack the right sideline. See Week 2 rankings. We ought to keep the same thing in mind about Ryan Fitzpatrick despite his Week 1 dominance. Read more. -- Jenna Laine, Bold prediction: Matt Ryan will have a 300-yard, three-touchdown day against Tampa Bay -- but it still results in a loss. What to know for fantasy: Chargers running back Austin Ekeler has converted just 15.4% of his career red zone carries (the RB average is 18%), so it's worth noting that rookie Joshua Kelley had more touches in the red zone in Week 1. And keep an eye on outside linebackers Melvin Ingram III, T.J. Watt and Alex Highsmith trying to minimize tight end Darren Waller -- a player who certainly has their attention after 19 targets a week ago. -- Nick Wagoner. ET | ESPN -- Rich Cimini, Bold prediction: The Patriots will make running back J.J. Taylor active as a result of rookie Rhamondre Stevenson's struggles in the opener, and Taylor's presence as a complement to Damien Harris and James White will be key against a Jets defense that blitzed 41.7% of the time in the opening week -- the fifth-highest total in the NFL. Matchup rating: 56.5 | Spread: SEA -6.0 (54), What to watch for: Seattle's defense must be licking its chops after watching the Titans allow six sacks in their blowout loss to Arizona in Week 1. Jets get help with WRs Crowder, Cole returning, Jets LT Becton to miss at least 4-6 weeks after dislocating knee cap, Jets' protection issues could be pain in neck for QB Wilson, Shirt on or shirt off, elite-version Miller has returned, Opening loss to Texans shows pass rush still a problem for Jaguars, Bridgewater makes the first impression Broncos hoped to see, How Burrow's expectations for himself, Bengals are creating success, Bears offer small glimpse of Fields' potential, Higgins to swap number: 'I'm not Ochocinco 2.0'. For whatever reason, Allen has had the most career success against the Dolphins. The entire city of Chicago is on edge over the Bears. Reiss' pick: Patriots 30, Jets 17 In the past four games that he has started and finished, he has thrown for at least 403 yards. Taking out Taylor's four carries for 40 yards, Houston ran for 120 yards on 37 carries in Week 1 (3.2 yards per carry) against Jacksonville. The first was the 1977 49ers, who bested the Saints twice. -- Jenna Laine, Game picks from our NFL experts FPI prediction: TEN, 72.4% (by an average of 8.5 points), Matchup must-reads: Jaguars' Henderson thinks great debut could have been even better Titans' Byard can share home-birth story with his son 'for the rest of our days' Minshew and rookies come up big in upset Fourth-quarter comebacks becoming routine for Tannehill, Titans, 1 p.m. Full schedule | Standings He had at least one catch on nine different route types last week, according to ESPN Stats & Information research using NFL Next Gen Stats. What to know for fantasy: The Bucs held Christian McCaffrey to 7.3 points in Week 2 last season. Matchup rating: 59.9 | Spread: NO -3.0 (44.5), What to watch for: Panthers quarterback Sam Darnold was sacked only once but hit seven times by an average Jets defensive front. Jets' protection issues could be pain in neck for QB Wilson, 1 p.m. What to know for fantasy: Chiefs wideout Tyreek Hill has 310.6 fantasy points over his past 12 games (playoffs included). Read more. The Saints' defense has taken the next-man-up mentality to the next level early this season, dominating despite several key players missing from last season. Berry: QBs, RBs, WRs and TEs I love -- and hate -- for Week 2, NFL experts predict: Week 2 upset picks and fantasy sleepers, plus what we're buying and selling, Barnwell: The NFL is back! Hurts' jersey sales surge 500% after Eagles' Week 1 win, 1 p.m. FPI prediction: BAL, 68.5% (by an average of 6.9 points), Matchup must-reads: Three ways Jackson is better than his MVP season Texans must quickly figure out what went wrong All virus tests negative from Texans' opener Texans squander chance to show they can thrive without Hopkins, 4:25 p.m. Matchup rating: 54.6 | Spread: SF -3.0 (49.5), What to watch for: This matchup is all about the explosive plays. -- Turron Davenport. What to know for fantasy: Indianapolis receiver Parris Campbell not only set career highs in routes (38), targets (9), catches (6), yards (71) and fantasy points (14) in Week 1, but he also led the team in deep targets (3). NFL Draft; NFL FPI; Total QBR; Injuries; More. Davenport's pick: Seahawks 28, Titans 24 What the Lions do -- and how well they do it -- might help determine what kind of coverages Rodgers sees throughout the season. Barshop's pick: Browns 27, Texans 17 4:25 p.m. What to know for fantasy: From 2017 to 2020, the 49ers ranked fourth in running back fantasy points. Stat to know: Mahomes and Lamar Jackson have the two highest Total QBRs among quarterbacks to appear in 10-plus prime-time games since the metric began in 2006. Matchup rating: 53.6 | Spread: PIT -7 (40.5), What to watch for: The Steelers shut down one of the league's premier running backs Monday night, allowing Saquon Barkley only 6 rushing yards. See Week 2 rankings. Also, keep an eye on Pittsburgh's Ben Roethlisberger; he needs three passing touchdowns to become the eighth NFL player with 400 passing touchdowns. The Seahawks got to Carson Wentz early and often in their opener. What to know for fantasy: New York quarterback Daniel Jones has run for at least 20 yards in five of his past seven games and thrown at least 40 passes in seven of his past nine. Keim's pick: Cardinals 21, Washington 17 Weinfuss' pick: Cardinals 31, Washington 24 FPI prediction: ARI, 68.2% (by an average of 6.8 points) Matchup must-reads: Young, Washington's pass rush 'as advertised' in promising start. Read more. Look for them to weaponize versatility again with guys such as Fitzpatrick, Cam Sutton, Tre Norwood. That's saying a lot considering how Tennessee gained a total of only four yards on their first four drives last week. It's the NFL's best interior defensive lineman against the league's best guard. Watson led the NFL with two such games in 2018, led again in 2019 with three such games and was one of two quarterbacks (Josh Allen) to accomplish the feat in Week 1 this season. Allen also has thrown more touchdown passes in 16 starts (36) than he did in 28 starts (32) before that game. -- Tim McManus, Bold prediction: 49ers running back Elijah Mitchell will go over 100 rushing yards for the second straight week to begin his rookie season. FREE to play! How Mayfield remade his body after a disappointing 2019, No setback, but Browns rule out OBJ vs. Texans. -- Mike Reiss. and dropped back to pass on 11 of their 14 first-quarter offensive plays against Atlanta. -- Mike Reiss. What to know for fantasy: Eagles tight end Dallas Goedert has 6.1 more fantasy points over his past five games than Zach Ertz does. Best game of the year. -- Jake Trotter, Bold prediction: The Browns hold the Texans to fewer than 50 rushing yards. Betting nugget: The over cashed in both Patriots-Jets games last season after being a winning ticket just once in the four seasons prior. You have come to the ESPN Africa edition, for other ESPN editions, click above. At 5-foot-8 and 185 pounds, he can play "hide and seek," according to running backs coach Ivan Fears, who has compared Taylor to Dion Lewis and Darren Sproles in terms of his physical stature. Buffalo Bills. Matchup rating: 61.9 | Spread: LAC -3.5 (40.5), What to watch for: Chargers quarterback Justin Herbert will be looking for Austin Ekeler through the air this week after the running back didn't have a catch in Week 1. NFL Power Rankings: Setting realistic rest-of-season expectations for all 32 teams. FPI prediction: CHI, 54.2% (by an average of 1.6 points), Matchup must-reads: How Burrow's expectations for himself, Bengals are creating success Bears offer small glimpse of Fields' potential Higgins to swap number: 'I'm not Ochocinco 2.0', 4:05 p.m. They were one of three teams that did not get a sack in their opener and the only team that didn't contact the quarterback while running or throwing. After Bills' sloppy mistakes led to season-opening loss, what's the message? FPI win projection: Chiefs, 75 percent. Read more. ESPN researcher Kyle Soppe hands out helpful fantasy football and betting nuggets, as well. But the most important aspect to watch on Sunday is how the Cardinals' front seven pressures the Vikings' offensive line and whether it can get to Kirk Cousins, who threw for 351 yards and two touchdowns last week. The Saints' defense has taken the next-man-up mentality to the next level early this season, dominating despite several key players missing from last season. 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