epinephrine and phenylephrine PO both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Avoid or Use Alternate Drug. Other (see comment). epinephrine and venlafaxine both increase QTc interval. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Coadministration may reduce nateglinide's hypoglycemic action. Thalidomide has been used by Brazilian physicians as the drug of choice for the treatment of severe ENL since 1965, and by 1996, at least 33 cases of thalidomide embryopathy were recorded in people born in Brazil after 1965. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Mechanism: unknown. Risk of V tach, HTN. prescription products. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. Use Caution/Monitor. Monitor Closely (1)methyldopa increases effects of epinephrine by unknown mechanism. Effect of interaction is not clear, use caution. Use Caution/Monitor. Mechanism: pharmacodynamic synergism. commonly, these are generic drugs. If you are taking this medication on a prescribed schedule, take it regularly in order to get the most benefit from it. Use Caution/Monitor. Monitor Closely (1)lofexidine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. As they were also epileptologists, they had some familiarity with the antiaggression effects of this drug. Contraindicated. fluvoxamine and epinephrine both increase QTc interval. [66] The severity and location of the deformities depended on how many days into the pregnancy the mother was before beginning treatment; thalidomide taken on the 20th day of pregnancy caused central brain damage, day 21 would damage the eyes, day 22 the ears and face, day 24 the arms, and leg damage would occur if taken up to day 28. Contraindicated. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug.imipramine, epinephrine. Use Caution/Monitor. Avoid taking antacids that contain magnesium while using misoprostol because they may make the diarrhea it causes worse. Information last revised October 2021. Use Caution/Monitor. Note: Ratio expression of epinephrine concentrations are prohibited on drug labels; however, some may remain in inventory (1:1000 = 1mg/mL; 1:10,000 = 0.1mg/mL), During a resuscitation effort, 0.5 mg (5 mL) IV q5min, Intracardiac injection if there has not been sufficient time to establish an IV route, Usual dose ranges from 0.3-0.5 mg (3-5 mL), Alternatively, if the patient has been intubated, epinephrine can be injected via the endotracheal tube directly into the bronchial tree at the same dosage as for IV injection, 2-2.5 mg q3-5min until IV/IO access established or spontaneous circulation restored, 0.1 mg IV at rate of 1-4 mcg/min over 5 min to prevent the need to repeat injections frequently OR may initiate with infusion at 5-15 mcg/min (with crystalloid administration); IV administration should only be done in patients who are profoundly hypotensive or are in cardiopulmonary arrest refractory to volume resuscitation and several epinephrine injections, 0.3-0.5 mg (0.3-0.5 mL) of undiluted epinephrine IM/SC once in anterolateral aspect of the thigh, not to exceed 0.5 mg (0.5 mL) per injection, repeated every 5-10 minutes as necessary, Monitor clinically for reaction severity and cardiac effects, 0.3 mg (contents of 1 autoinjector) SC/IM once in anterolateral aspect of the thigh; may repeat dose after 5-15 minutes if symptoms persist, Dilute 1 mg (of 1 mg/mL single-use solution) to 1-10 mcg/mL, Dilute 1 mg (of 1 mg/mL single-use solution) to 2.5-10 mcg/mL, With severe persistent anaphylaxis, repeat injections with an additional autoinjector may be necessary, More than two sequential doses of epinephrine should only be administered under direct medical supervision, 0.15mg/0.15mL (EpiPen Jr, Auvi-Q, Symjepi), <30 kg (66 lbs): 0.01 mg/kg (0.01 mL/kg) SC/IM, not to exceed 0.3 mg (0.3 mL) per injection, repeated q5-10 min as necessary, 30 kg (66 lbs): 0.3-0.5 mg (0.3-0.5 mL) SC/IM, not to exceed 0.5 mg (0.5 mL) per injection, repeated q5-10 min as necessary, May repeat dose after 5-15 minutes if symptoms persist, Infants weighing 7.5-15 kg (16.5-33 lb); Auvi-Q only: 0.1 mg SC/IM once, Weight 15 to <30 kg: 0.15 mg (contents of 1 autoinjector/prefilled syringe) SC/IM once; may repeat dose q5-15min, Weight 30 kg: 0.3 mg (contents of 1 autoinjector/prefilled syringe) SC/IM once; may repeat dose q5-15min, 0.1 mg/mL solution: 0.01 mg/kg (0.1 mL/kg) IO/IV; not to exceed 1 mg/dose, May repeat q3-5min until return of spontaneous circulation, 1 mg/mL solution: 0.1 mg/kg (0.1 mL/kg) endotracheal; not to exceed 2.5 mg/dose, May repeat every 3-5 minutes prn until IV/IO access established, sodium sulfate/potassium sulfate/magnesium sulfate/polyethylene glycol, To prevent sloughing and necrosis in areas has extravasation, infiltrate the area with 10-15 mL of 0.9% NaCl solution containing phentolamine 5-10 mg, Use a syringe with a fine hypodermic needle, with solution being infiltrated liberally throughout the area, which has a cold, hard, and pallid appearance, Phentolamine may cause immediate and conspicuous local hyperemic changes if area is infiltrated within 12 hr, Injection into buttock may not provide effective treatment of anaphylaxis, Accidental injection into hands, digits, or feet may result in local reactions including injection site coldness, pallor, and hypoesthesia or injury resulting in bruising, discoloration, erythema, bleeding, or skeletal injury, To minimize the risk of injection-related injury when administering autoinjector to children or infants, instruct caregivers to firmly hold childs leg in place and limit movement prior to and during injection, Coadministration with cardiac glycosides, diuretics, or anti-arrhythmics should be observed carefully for the development of cardiac arrhythmias, Effects of epinephrine may be potentiated by tricyclic antidepressants, monoamine oxidase inhibitors, levothyroxine sodium, and certain antihistamines, notably chlorpheniramine, tripelennamine, and diphenhydramine, Cardiostimulating and bronchodilating effects of epinephrine are antagonized by beta-adrenergic blocking drugs, such as propranolol, Vasoconstricting and hypertensive effects of epinephrine are antagonized by alpha-adrenergic blocking drugs, such as phentolamine, Ergot alkaloids may reverse the pressor effects of epinephrine, Epinephrine usually inhibits spontaneous or oxytocin-induced contractions of the pregnant human uterus and may delay second stage of labor; avoid epinephrine during second stage of labor; in dosage sufficient to reduce uterine contractions, the drug may cause a prolonged period of uterine atony with hemorrhage, Avoid epinephrine in obstetrics when maternal blood pressure exceeds 130/80 mmHg; although epinephrine may improve maternal hypotension associated with septic shock and anaphylaxis, it may result in uterine vasoconstriction, decreased uterine blood flow, and fetal anoxia, Store at room temperature, 20-25C (68-77F), Protect from light until ready to use; do not refrigerate; protect from freezing, Protect from alkalis and oxidizing agents, Store at room temperature (25C) or refrigeration (4C) is 24 hr, Store at room temperature 20-25C (68-77F); excursions permitted to 15-30C (59-86F; do not refrigerator, The trainer for AUVI-Q should not be used at temperatures <50F (10C) or >104F (40C), Store the trainer for AUVI-Q in its outer case; keep away from dirt, chemicals, and water. Effect of interaction is not clear, use caution. Use Caution/Monitor. Inform your doctor if your condition does not improve or if it worsens. dopexamine and epinephrine both decrease serum potassium. Use Caution/Monitor. Use Caution/Monitor. Call your doctor at once if you notice pain, swelling, warmth, redness, or other signs of infection around the area where you gave an injection. Effect of interaction is not clear, use caution. Use Caution/Monitor. Other (see comment). Use Caution/Monitor. [9][10] While it was initially thought to be safe in pregnancy, concerns regarding birth defects arose until the medication was removed from the market in Europe in 1961. amoxapine, epinephrine. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use EpiPen only for the indication prescribed. Avoid or Use Alternate Drug. Effect of interaction is not clear, use caution. labetalol increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Most Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Effect of interaction is not clear, use caution. Effect of interaction is not clear, use caution. Monitor Closely (1)epinephrine and torsemide both decrease serum potassium. Thalidomide may interfere with various contraceptives, and hence it is advised that women of reproductive age use at least two different means of contraception to ensure that no child will be conceived while they are taking thalidomide. Monitor Closely (1)epinephrine decreases effects of insulin degludec by pharmacodynamic antagonism. Monitor Closely (1)epinephrine and levofloxacin both increase QTc interval. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. Use Caution/Monitor.epinephrine and pirbuterol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Monitor Closely (1)pholcodine increases and epinephrine decreases sedation. epinephrine, ethacrynic acid. Other (see comment). Effect of interaction is not clear, use caution. Monitor Closely (1)epinephrine and caffeine both decrease sedation. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Effect of interaction is not clear, use caution. nortriptyline increases and epinephrine decreases sedation. Monitor Closely (2)timolol decreases effects of epinephrine by pharmacodynamic antagonism. EpiPen Auto-Injectors may be kept on hand for self-injection by a person with a history of severe allergic reaction. This medication protects your stomach lining by lowering the amount of acid that comes in contact with it.This medication is also used in combination with another drug (mifepristone) to end a pregnancy (abortion). paliperidone increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Does Zofran interact with other drugs you are taking? Serious - Use Alternative (1)dihydroergotamine, epinephrine. Risk of acute hypertensive episode. Caution is advised. Mechanism: pharmacodynamic synergism. Tips for Providing In-Flight Assistance, Ever Treat a Patient on a Plane? WebMany people using this medication do not have serious side effects. epinephrine and foscarnet both increase QTc interval. Modify Therapy/Monitor Closely. aspirin/citric acid/sodium bicarbonate increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug. Since epinephrine can save your life, using it is more important than avoiding any sulfite-related problems.Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart problems (such as angina, irregular heartbeat), high blood pressure, thyroid disease, diabetes.This drug may make you dizzy. This drug is available at a higher level co-pay. Store at or below 77 degrees F (25 degrees C) in a dry place away from light and moisture. Use Caution/Monitor.imipramine increases effects of epinephrine by unknown mechanism. Use Caution/Monitor. Monitor Closely (1)lorazepam increases and epinephrine decreases sedation. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (2)epinephrine and yohimbine both decrease sedation. WebPioglitazone, sold under the brand name Actos among others, is an anti-diabetic medication used to treat type 2 diabetes. Use Caution/Monitor. Avoid or Use Alternate Drug. spironolactone increases and epinephrine decreases serum potassium. Monitor Closely (2)dichlorphenamide and epinephrine both decrease serum potassium. phenobarbital increases and epinephrine decreases sedation. celecoxib increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. epinephrine and dextroamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Use Caution/Monitor. epinephrine and solriamfetol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Be sure to have clear instructions from your doctor about who to call and what to do in case of an emergency. Serious - Use Alternative (1)propofol increases levels of epinephrine by unknown mechanism. Use Caution/Monitor. Effect of interaction is not clear, use caution. digoxin increases and epinephrine decreases serum potassium. Use Caution/Monitor.epinephrine and metaproterenol both decrease sedation. Use Caution/Monitor. Mechanism: pharmacodynamic synergism. Bretylium causes an initial norepinephrine release and may enhance catecholamine pressor effects. [2] Also, rare case reports of an auditory side effect have been made, whereby patients perceive sounds about a semitone lower than previously; this unusual side effect is usually not noticed by most people, and disappears after the person stops taking carbamazepine. oxymorphone increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Diarrhea that doesn't go away may sometimes lead to a large loss of your body's water and minerals. Serious - Use Alternative (1)levomilnacipran increases levels of epinephrine by pharmacodynamic synergism. Call your doctor at once if you have: very slow heartbeats; a epinephrine and protriptyline both increase QTc interval. Use Caution/Monitor. Use your next dose at the regular time. buprenorphine buccal increases and epinephrine decreases sedation. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Sue Kent, born in 1963 with phocomelia of both arms, eight inches long, no thumbs, and seven fingers three on one hand, four on the other - has appeared as a presenter on the BBC TV show "Gardener's World" since 2020, demonstrating her ability to garden using her feet and toes where others would use their hands. Interaction more likely in certain predisposed pts. Use Caution/Monitor. Avoid or Use Alternate Drug. Mechanism: pharmacodynamic synergism. You may report side effects to Health Canada at 1-866-234-2345. Monitor Closely (1)epinephrine and sodium sulfate/potassium sulfate/magnesium sulfate/polyethylene glycol both decrease serum potassium. See how UpToDate improves outcomes while reducing costs. Minor (1)eucalyptus increases and epinephrine decreases sedation. Use Caution/Monitor. WebOlder adults may be more sensitive to the side effects of this drug, especially QT prolongation (see above). Use Caution/Monitor.promethazine, epinephrine. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. WebOlder adults may be more sensitive to the side effects of this drug, especially QT prolongation (see above). Your medicine may also come with a "trainer pen." Carbamazepine appears to work as well as only. If you log out, you will be required to enter your username and password the next time you visit. In the US, the label for carbamazepine contains warnings concerning: Common adverse effects may include drowsiness, dizziness, headaches and migraines, motor coordination impairment, nausea, vomiting, and/or constipation. WebMetoprolol Tartrate side effects. Use Caution/Monitor. Interaction more likely in certain predisposed pts. penbutolol increases and epinephrine decreases serum potassium. Additive vasospasm; risk of hypertension. epinephrine and erythromycin ethylsuccinate both increase QTc interval. Risk of hypertension and bradycardia. Effect of interaction is not clear, use caution. oxaprozin increases and epinephrine decreases serum potassium. Before using this medication, tell your doctor or pharmacist your medical history, especially of: stomach/intestinal disease (such as inflammatory bowel disease). Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor.Minor (1)epinephrine, bumetanide. Use Caution/Monitor. trimipramine increases and epinephrine decreases sedation. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. Use Caution/Monitor. Contraindicated (1)epinephrine and sotalol both increase QTc interval. morphine increases and epinephrine decreases sedation. ephedrine and epinephrine both decrease sedation. [35] Celgene Corporation's original method resulted in a 31% yield of S-thalidomide, whereas the two-step synthesis yields 8593% product that is 99% pure. If you are experiencing vision issues, it could be the result of a drug you were on but are no longer taking. Risk of V tach, HTN. Effect of interaction is not clear, use caution. QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away. Use Caution/Monitor. Mechanism: unknown. Monitor Closely (1)pentazocine increases and epinephrine decreases sedation. [33] It binds preferentially to voltage-gated sodium channels in their inactive conformation, which prevents repetitive and sustained firing of an action potential. Effect of interaction is not clear, use caution. Effect of interaction is not clear, use caution. succinylcholine increases and epinephrine decreases serum potassium. ziprasidone increases and epinephrine decreases sedation. benperidol increases and epinephrine decreases sedation. Monitor Closely (1)diamorphine increases and epinephrine decreases sedation. Monitor Closely (1)oxazepam increases and epinephrine decreases sedation. ether increases toxicity of epinephrine by Mechanism: unknown. Monitor Closely (2)amitriptyline increases effects of epinephrine by unknown mechanism. Canada residents can call a provincial poison control center. [6] While it has been used in a number of HIV-associated conditions, such use is associated with increased levels of the virus. Use Caution/Monitor. During pregnancy, this medication should be used only when clearly needed. Modify Therapy/Monitor Closely. Monitor Closely (2)acebutolol decreases effects of epinephrine by pharmacodynamic antagonism. Avoid or Use Alternate Drug. only.prochlorperazine decreases effects of epinephrine by pharmacodynamic antagonism. Monitor Closely (1)oxaprozin increases and epinephrine decreases serum potassium. Carbamazepine, as an inducer of cytochrome P450 enzymes, may increase clearance of many drugs, decreasing their concentration in the blood to subtherapeutic levels and reducing their desired effects. Serious - Use Alternative (1)epinephrine and fluconazole both increase QTc interval. Hypertension, V tach. Effect of interaction is not clear, use caution. Effect of interaction is not clear, use caution. Use Caution/Monitor.epinephrine, epinephrine racemic. Use Caution/Monitor. Use Caution/Monitor. epinephrine and norepinephrine both decrease sedation. [48] It was not until March 1962, that both drugs were banned from the Canadian market by the FDD and, soon afterward, physicians were warned to destroy their supplies. epinephrine, metolazone. Monitor Closely (1)topiramate increases and epinephrine decreases sedation. Call your doctor at once if you have: very slow heartbeat, excessive tiredness, or chest pain; Hold the leg firmly when giving this injection to a child or infant. Monitor Closely (1)epinephrine, epinephrine inhaled. Their advertisement claimed that "Distaval can be given with complete safety to pregnant women and nursing mothers without adverse effect on mother or child Outstandingly safe Distaval has been prescribed for nearly three years in this country. EpiPen side effects. Use Caution/Monitor.epinephrine and dextroamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. While it has been used in a number of HIV-associated conditions, such use is associated with Use Caution/Monitor.Minor (1)epinephrine, torsemide. lofepramine increases and epinephrine decreases sedation. Diarrhea is common with misoprostol and usually occurs about two weeks after you start taking it, and lasts for about a week. [29][30], Thalidomide is racemic; while S-thalidomide is the bioactive form of the molecule, the individual enantiomers can racemize to each other due to the acidic hydrogen at the chiral centre, which is the carbon of the glutarimide ring bonded to the phthalimide substituent. Use Caution/Monitor. Effect of interaction is not clear, use caution. Use Caution/Monitor. Modify Therapy/Monitor Closely. Hold the Auto-Injector in place for a few seconds after activation. Monitor Closely (2)epinephrine and methylenedioxymethamphetamine both decrease sedation. Use Caution/Monitor.Serious - Use Alternative (1)epinephrine and perphenazine both increase QTc interval. If you are taking this drug to prevent stomach ulcers, take it by mouth usually four times a day, after meals and at bedtime to minimize diarrhea, or as directed by your doctor. nortriptyline increases and epinephrine decreases sedation. Additive vasospasm; risk of hypertension. epinephrine increases effects of indacaterol, inhaled by Other (see comment). Effect of interaction is not clear, use caution. Avoid or Use Alternate Drug.amitriptyline, epinephrine. The recipient will receive more details and instructions to access this offer. Use Caution/Monitor.nadolol decreases effects of epinephrine by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. epinephrine and maprotiline both increase QTc interval. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. If you notice other effects not listed above, contact your doctor or pharmacist. perphenazine increases and epinephrine decreases sedation. Also seek emergency medical attention if you accidentally inject yourself while giving EpiPen to another person. methyldopa increases effects of epinephrine by unknown mechanism. Etonogestrel is effective as a means [15], The drug is also claimed to be effective for ADHD. Thalidomide can prevent menstruation. Use Caution/Monitor. epinephrine and pirbuterol both decrease serum potassium. Use Caution/Monitor. dopexamine and epinephrine both decrease sedation. Monitor Closely (2)pindolol decreases effects of epinephrine by pharmacodynamic antagonism. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. Use Caution/Monitor. Carbamazepine appears to work as well as << /Type /XRef /Filter /FlateDecode /Length 303 /W [ 1 3 1 ] /Index [ 273 133 ] Monitor Closely (3)epinephrine and salmeterol both decrease serum potassium. Contraindicated. The medication is available in both low-dose and high-dose formulations and both alone and in combination with an estrogen. Monitor Closely (1)atomoxetine, epinephrine. Because the active metabolite of ozanimod inhibits MAO-B in vitro, there is a potential for serious adverse reactions, including hypertensive crisis. [88], There is no conclusive evidence that thalidomide or lenalidomide is useful to bring about or maintain remission in Crohn's disease. The underbanked represented 14% of U.S. households, or 18. Therefore, coadministration of ozanimod with drugs that can increase norepinephrine or serotonin is not recommended. Hypokalemia. Do not refrigerate this medication, and do not store it in a car. Serious - Use Alternative (1)ketamine, epinephrine. It is not known whether this drug passes into breast milk. Use Caution/Monitor. Use Caution/Monitor. Effect of interaction is not clear, use caution. triprolidine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Effect of interaction is not clear, use caution. %PDF-1.7 Use Caution/Monitor. butabarbital increases and epinephrine decreases sedation. ` a6aav{e@jpbMlbSw#)r")r")r")r")r")r")r")r")r. Effect of interaction is not clear, use caution. Monitor Closely (2)epinephrine and dexmethylphenidate both decrease sedation. propranolol increases effects of epinephrine by pharmacodynamic synergism. fluphenazine increases and epinephrine decreases sedation. bisoprolol increases and epinephrine decreases serum potassium. dimenhydrinate increases and epinephrine decreases sedation. Mild side effects include: Fatigue; Use Caution/Monitor. To prevent nausea from radiation treatment, take this medication by mouth 1 to 2 hours before the start of your treatment. [56], Judah Folkman pioneered studies into the role of angiogenesis (the proliferation and growth of blood vessels) in the development of cancer, and in the early 1970s had shown that solid tumors could not expand without it. clonazepam increases and epinephrine decreases sedation. Does Zofran interact with other medications? Epinephrine works quickly to improve breathing, stimulate the heart, raise a dropping blood pressure, reverse hives, and reduce swelling of the face, lips, and throat. Minor/Significance Unknown. During pregnancy, this medication should be used only when clearly needed. Mechanism: pharmacodynamic synergism. nadolol increases and epinephrine decreases serum potassium. tolmetin increases and epinephrine decreases serum potassium. Monitor Closely (2)epinephrine and dopamine both decrease sedation. Effect of interaction is not clear, use caution. provider for the most current information. Use Caution/Monitor. These health conditions include both physical and psychological conditions. [80] Of these babies born with TE, "about 40% of them died before their first birthday". perphenazine increases and epinephrine decreases sedation. Mechanism: unknown. Risk of hypertension and bradycardia. imipramine increases and epinephrine decreases sedation. Caution is advised. Before using EpiPen a second time, tell your doctor if your first injection caused a serious side effect such as increased breathing difficulty, or dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure). Hypokalemia. Monitor Closely (1)potassium acid phosphate increases and epinephrine decreases serum potassium. Avoid or Use Alternate Drug. potassium acid phosphate increases and epinephrine decreases serum potassium. WebEtonogestrel is a medication which is used as a means of birth control for women. ephedrine and epinephrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. [1][12] However, evidence does not support this usage. Minor/Significance Unknown. Effect of interaction is not clear, use caution. [43] There soon appeared reports of abnormalities in children being born to mothers using thalidomide. Additive vasospasm; risk of hypertension. Adding plans allows you to compare formulary status to other drugs in the same class. Use Caution/Monitor. The EpiPen Auto-Injector device is a disposable single-use system. Monitor Closely (1)meprobamate increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. It is also used to prevent and treat nausea and vomiting after surgery. Avoid or Use Alternate Drug. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. amiloride increases and epinephrine decreases serum potassium. WebEpilepsy is a group of non-communicable neurological disorders characterized by recurrent epileptic seizures. Effect of interaction is not clear, use caution. Effect of interaction is not clear, use caution. Minor/Significance Unknown. loxapine inhaled increases and epinephrine decreases sedation. Use Caution/Monitor. The company demanded approval six times, and was refused each time. May increase risk for supine hypertension. only.promethazine decreases effects of epinephrine by pharmacodynamic antagonism. Use Caution/Monitor. WebEPI Treatments. Additive vasospasm; risk of hypertension. Use Caution/Monitor. If you are using this medication to start labor, your healthcare professional will insert it into your vagina. oxymetazoline topical and epinephrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Use Caution/Monitor.Serious - Use Alternative (2)epinephrine and desipramine both increase QTc interval. secobarbital increases and epinephrine decreases sedation. Monitor Closely (2)celiprolol decreases effects of epinephrine by pharmacodynamic antagonism. lormetazepam increases and epinephrine decreases sedation. Mechanism: pharmacodynamic synergism. Effect of interaction is not clear, use caution. Mechanism: pharmacodynamic synergism. Available for Android and iOS devices. Minor/Significance Unknown. epinephrine and clarithromycin both increase QTc interval. desmopressin increases effects of epinephrine by pharmacodynamic synergism. Avoid or Use Alternate Drug. [48], In 1964, Israeli physician Jacob Sheskin administered thalidomide to a patient critically ill with leprosy. haloperidol increases and epinephrine decreases sedation. If you are experiencing vision issues, it could be the result of a drug you were on but are no longer taking. Serious - Use Alternative (1)epinephrine and erythromycin ethylsuccinate both increase QTc interval. Use Caution/Monitor. A clinical trial studying the use of thalidomide in leprosy soon followed.[49]. WebAndrogen replacement therapy (ART), often referred to as testosterone replacement therapy (TRT) or hormone replacement therapy (HRT), is a form of hormone therapy in which androgens, often testosterone, are supplemented or replaced exogenously.ART is often prescribed to counter the effects of male hypogonadism.It typically involves the epinephrine and metaproterenol both decrease sedation. Use Caution/Monitor.epinephrine and isoproterenol both decrease sedation. Avoid or Use Alternate Drug.nortriptyline, epinephrine. Effect of interaction is not clear, use caution. Monitor Closely (1)rasagiline increases effects of epinephrine by pharmacodynamic synergism. You may report side effects to FDA at 1-800-FDA-1088. prochlorperazine decreases effects of epinephrine by pharmacodynamic antagonism. Either increases effects of the other by pharmacodynamic synergism. Minor (1)desmopressin increases effects of epinephrine by pharmacodynamic synergism. Avoid or Use Alternate Drug. If coadministered, monitor for changes in heart rate, heart rhythm, and blood pressure. Mechanism: pharmacodynamic synergism. Monitor Closely (1)alfentanil increases and epinephrine decreases sedation. Common LASIK Side Effects. doxepin increases and epinephrine decreases sedation. Use Caution/Monitor. Block pressor response to epinephrine, which may result in severe hypotension and tachycardia. Effect of interaction is not clear, use caution. Use Caution/Monitor. Use Caution/Monitor. Effect of interaction is not clear, use caution. epinephrine and droperidol both increase QTc interval. [22] No specific antidote for overdose exists and treatment is purely supportive. Avoid concomitant use if possible. Monitor Closely (1)tapentadol increases and epinephrine decreases sedation. Use Caution/Monitor. [45], The US FDA refused to approve thalidomide for marketing and distribution. aceclofenac increases and epinephrine decreases serum potassium. Use Caution/Monitor. epinephrine and artemether/lumefantrine both increase QTc interval. Use Caution/Monitor. Combinations of medications can contribute to a variety of eye-related side effects as well. Avoid or Use Alternate Drug.amoxapine, epinephrine. only.thioridazine decreases effects of epinephrine by pharmacodynamic antagonism. Effect of interaction is not clear, use caution. Use Caution/Monitor. You will need to receive further treatment and observation. Before using EpiPen, tell your doctor if any past use has caused an allergic reaction to get worse. The medication that your doctor chooses to treat your epilepsy depends on the type of seizures you have, as well as other factors such as your age and other health conditions. Monitor Closely (1)epinephrine decreases effects of insulin inhaled by pharmacodynamic antagonism. Monitor Closely (1)aceclofenac increases and epinephrine decreases serum potassium. Use Caution/Monitor. Monitor Closely (1)opicapone will increase the level or effect of epinephrine by decreasing metabolism. Do not store this medication in your vehicle or in the bathroom. epinephrine and xylometazoline both decrease sedation. Contraindicated. methylergonovine, epinephrine. Effect of interaction is not clear, use caution. Use Caution/Monitor. loprazolam increases and epinephrine decreases sedation. Other (see comment). Use Caution/Monitor.timolol decreases effects of epinephrine by pharmacodynamic antagonism. epinephrine, furosemide. quetiapine increases and epinephrine decreases sedation. Hypokalemia. Use Caution/Monitor.penbutolol decreases effects of epinephrine by pharmacodynamic antagonism. Use Caution/Monitor. epinephrine and erythromycin lactobionate both increase QTc interval. Avoid or Use Alternate Drug. Our Creon Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. oxycodone increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Effect of interaction is not clear, use caution. Effect of interaction is not clear, use caution. Concentrations in the breast milk are 25 to 60% of those in the blood plasma. [13][14][21] The U.S. Food and Drug Administration (FDA) and other regulatory agencies have approved marketing of the drug only with an auditable risk evaluation and mitigation strategy that ensures that people using the drug are aware of the risks and avoid pregnancy; this applies to both men and women, as the drug can be transmitted in semen. Monitor Closely (1)loxapine increases and epinephrine decreases sedation. The medication is available in both low-dose and high-dose formulations and both alone and in combination with an estrogen. WebAnabolic steroids, also known more properly as anabolicandrogenic steroids (AAS), are steroidal androgens that include natural androgens like testosterone as well as synthetic androgens that are structurally related and have similar effects to testosterone. Monitor Closely (1)choline magnesium trisalicylate increases and epinephrine decreases serum potassium. Avoid or Use Alternate Drug. epinephrine and lisdexamfetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Hypokalemia. Risk of acute hypertensive episode. Effect of interaction is not clear, use caution. Epipen (epinephrine injection) is given as an intramuscular (in the muscle) or subcutaneous (under the skin) injection only in the middle of the outer side of the thigh (the upper leg). Risk of V tach, HTN. Use Caution/Monitor. Use Caution/Monitor. Effect of interaction is not clear, use caution. epinephrine and posaconazole both increase QTc interval. Monitor Closely (1)dexmedetomidine increases and epinephrine decreases sedation. Use Caution/Monitor.Serious - Use Alternative (1)epinephrine and chlorpromazine both increase QTc interval. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Use Caution/Monitor. Use Caution/Monitor. See how UpToDate improves outcomes while reducing costs. During pregnancy, this medication should be used only when clearly needed. Use Caution/Monitor. trifluoperazine increases and epinephrine decreases sedation. >> Use Caution/Monitor. The trainer pen contains no medicine and no needle. Use Caution/Monitor. Use Caution/Monitor. epinephrine and dopamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. It can be injected through clothing if needed. Monitor Closely (2)betaxolol decreases effects of epinephrine by pharmacodynamic antagonism. Use Caution/Monitor. Effect of interaction is not clear, use caution. Use Caution/Monitor. Use Caution/Monitor.epinephrine and methylenedioxymethamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Monitor Closely (2)epinephrine and xylometazoline both decrease sedation. Effect of interaction is not clear, use caution. Avoid or Use Alternate Drug. Additive vasospasm; risk of hypertension. Side effects may be more likely in older adults. Monitor Closely (2)promazine, epinephrine. Use Caution/Monitor.amitriptyline increases effects of epinephrine by unknown mechanism. Effect of interaction is not clear, use caution. Use Caution/Monitor. epinephrine and dexfenfluramine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. People are classified as obese when their body mass index (BMI)a person's weight divided by the square of the person's heightis over 30 kg/m 2; the range 2530 kg/m 2 is defined as overweight. Use Caution/Monitor. Effect of interaction is not clear, use caution. Consult your pharmacist or local waste disposal company. Store tablets in the refrigerator or at room temperature away from light and moisture. Monitor Closely (1)midazolam increases and epinephrine decreases sedation. Use Caution/Monitor. Effect of interaction is not clear, use caution. Serious - Use Alternative (1)epinephrine and artemether/lumefantrine both increase QTc interval. Share cases and questions with Physicians on Medscape consult. Monitor Closely (3)arformoterol and epinephrine both decrease serum potassium. Effect of interaction is not clear, use caution. Risk of V tach, HTN. Use Caution/Monitor. commonly, these are "non-preferred" brand drugs or specialty trifluoperazine decreases effects of epinephrine by pharmacodynamic antagonism. Use Caution/Monitor. WebNorethisterone, also known as norethindrone and sold under many brand names, is a progestin medication used in birth control pills, menopausal hormone therapy, and for the treatment of gynecological disorders. It is used by Use Caution/Monitor. Use Caution/Monitor. Contraindicated. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. This is not a complete list of side effects and others may occur. Effect of interaction is not clear, use caution. Monitor Closely (1)phentolamine, epinephrine. Do not start, stop, or change the dosage of any medicines without your doctor's approval. [14] Carbamazepine is the only medication that is FDA-approved for the treatment of trigeminal neuralgia. Other (see comment). Use Caution/Monitor. Effect of interaction is not clear, use caution. Contraindicated. Use Caution/Monitor.epinephrine and phenylephrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Get medical help right away if you develop some of the following symptoms: fast heartbeat, hallucinations, loss of coordination, severe dizziness, severe nausea/vomiting/diarrhea, twitching muscles, unexplained fever, unusual agitation/restlessness. Properly discard this product when it is expired or no longer needed. Use Caution/Monitor.epinephrine and methamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. thioridazine decreases effects of epinephrine by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Read the latest information and advice about fourth doses of COVID-19 vaccines for people aged 30 and over. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely. Overdose symptoms may include numbness or weakness, severe headache, blurred vision, pounding in your neck or ears, sweating, chills, chest pain, fast or slow heartbeats, severe shortness of breath, or cough with foamy mucus. epinephrine and nortriptyline both increase QTc interval. Use Caution/Monitor. Monitor Closely (2)epinephrine and dextroamphetamine both decrease sedation. desipramine increases and epinephrine decreases sedation. Avoid or Use Alternate Drug. WebCarbamazepine (CBZ), sold under the trade name Tegretol among others, is an anticonvulsant medication used primarily in the treatment of epilepsy and neuropathic pain. Use Caution/Monitor.Minor (1)epinephrine, furosemide. Use Caution/Monitor. Risk of hypertension and bradycardia. Use Caution/Monitor.chlorpromazine, epinephrine. The half-life can be further shortened to 910 hours by other enzyme inducers such as phenytoin or phenobarbital. This medication may be taken with or without food. Use Caution/Monitor. [13][14], Thalidomide can cause liver damage and severe skin reactions like StevensJohnson syndrome. etomidate increases levels of epinephrine by decreasing metabolism. The above information is provided for general Carefully re-insert the used device needle-first into the carrying tube. WebWeight loss, in the context of medicine, health, or physical fitness, refers to a reduction of the total body mass, by a mean loss of fluid, body fat (adipose tissue), or lean mass (namely bone mineral deposits, muscle, tendon, and other connective tissue).Weight loss can either occur unintentionally because of malnourishment or an underlying disease, or from a . Read the latest information and advice about fourth doses of COVID-19 vaccines for people aged 30 and over. After LASIK surgery, you're likely to experience side effects. Effect of interaction is not clear, use caution. Monitor Closely (1)epinephrine and chlorthalidone both decrease serum potassium. Use Caution/Monitor. If you have any questions about this drug, ask your doctor, nurse, or pharmacist. [58] Folkman persuaded the patient's doctor to try thalidomide, and that doctor conducted a clinical trial of thalidomide for people with multiple myeloma in which about a third of the subjects responded to the treatment. Nausea or stomach cramps may occur. Seek emergency medical attention right away after using the injection. [36] In 1957, it was acquired by Chemie Grnenthal in Germany. Modify Therapy/Monitor Closely. Things to remember when you fill your prescription. Monitor Closely (1)epinephrine and venlafaxine both increase QTc interval. If you have any questions, ask your doctor or pharmacist.Keep this product near you at all times. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. epinephrine and modafinil both decrease sedation. Effect of interaction is not clear, use caution. Monitor Closely (1)levothyroxine will increase the level or effect of epinephrine by unspecified interaction mechanism. Effect of interaction is not clear, use caution. Use Caution/Monitor. /Size 406 /Prev 888777 Use Caution/Monitor. Epinephrine may enhance hypotensive effects of lurasidone in overdose setting. Contraindicated. Use Caution/Monitor. trimipramine, epinephrine. Use Caution/Monitor. It is taken by mouth.. Common side effects include headaches, muscle Block pressor response to epinephrine, which may result in severe hypotension and tachycardia. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. amoxapine increases and epinephrine decreases sedation. Contraindicated (1)epinephrine and disopyramide both increase QTc interval. WebLopressor may also be used for other purposes not listed in this medication guide. Use Caution/Monitor. albuterol and epinephrine both decrease sedation. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Effect of interaction is not clear, use caution. Effect of interaction is not clear, use caution. Effect of interaction is not clear, use caution. Avoid or Use Alternate Drug. epinephrine and norepinephrine both decrease serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. Effect of interaction is not clear, use caution. epinephrine and epinephrine racemic both decrease sedation. Avoid or Use Alternate Drug. Monitor Closely (2)epinephrine and benzphetamine both decrease sedation. It is used as an adjunctive treatment in schizophrenia along with other medications and as a second-line agent in bipolar disorder. Use Caution/Monitor. Caution if coadministered with drugs metabolized by COMT. entacapone will increase the level or effect of epinephrine by decreasing metabolism. Learn ahead of time how to properly inject this medication so you will be ready if you need to use it. epinephrine and midodrine both decrease sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. Minor/Significance Unknown. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Those allergic to thalidomide should not take it. Use Caution/Monitor. The proton pump is the terminal stage in gastric acid secretion, being directly responsible for secreting H + ions into the gastric lumen, making Use Caution/Monitor. Monitor Closely (1)epinephrine and fluoxetine both increase QTc interval. primidone increases and epinephrine decreases sedation. Use Caution/Monitor. Use Caution/Monitor. Minor/Significance Unknown. Contraindicated. Monitor Closely (1)butorphanol increases and epinephrine decreases sedation. xZmS9_uZ* *$\v`Sxr=1f\*5f~ojZJ(FnZ'7h y^DDA :M$9XiA1PBz@0WB"yd>A(& Monitor Closely (1)ketorolac intranasal increases and epinephrine decreases serum potassium. opium tincture increases and epinephrine decreases sedation. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Modify Therapy/Monitor Closely. Use Caution/Monitor. Effect of interaction is not clear, use caution. epinephrine and salmeterol both decrease serum potassium. aripiprazole increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Effect of interaction is not clear, use caution. Use Caution/Monitor. diclofenac increases and epinephrine decreases serum potassium. Modify Therapy/Monitor Closely. Use Caution/Monitor. In the UK, the British pharmaceutical company The Distillers Company (Biochemicals) Ltd, a subsidiary of Distillers Co. Ltd (now part of Diageo plc), marketed thalidomide throughout the UK, Australia and New Zealand, under the brand name Distaval, as a remedy for morning sickness. Mechanism: unknown. Avoid or Use Alternate Drug. Use Caution/Monitor. desflurane increases toxicity of epinephrine by Mechanism: unknown. Risk of acute hypertensive episode. Effect of interaction is not clear, use caution. Use Caution/Monitor. epinephrine and dolasetron both increase QTc interval. Use Caution/Monitor.arformoterol and epinephrine both decrease sedation. Effect of interaction is not clear, use caution. Contraindicated.Monitor Closely (1)epinephrine and indapamide both decrease serum potassium. Serious - Use Alternative (1)epinephrine will decrease the level or effect of iobenguane I 131 by Other (see comment). It is not known if EpiPen is safe and effective in children who weigh less than 33 pounds (15 kilograms). Effect of interaction is not clear, use caution. Monitor Closely (1)selegiline increases effects of epinephrine by pharmacodynamic synergism. Use Caution/Monitor. [84] In 2005, Celgene received FDA approval for lenalidomide (Revlimid) as the first commercially useful derivative. Effect of interaction is not clear, use caution. only. Call your doctor at once if you have: very slow heartbeat, excessive tiredness, or chest pain; Monitor Closely (1)scullcap increases and epinephrine decreases sedation. . Use Caution/Monitor. If coadministered, monitor for changes in heart rate, heart rhythm, and blood pressure. Pomalidomide was approved in February 2013 by the U.S. Food and Drug Administration (FDA) as a treatment for relapsed and refractory multiple myeloma. epinephrine decreases effects of insulin inhaled by pharmacodynamic antagonism. Effect of interaction is not clear, use caution. Copyright(c) 2022 First Databank, Inc. Call your doctor for medical advice about side effects. albuterol and epinephrine both decrease serum potassium. epinephrine and dextroamphetamine both decrease sedation. Monitor Closely (1)epinephrine and armodafinil both decrease sedation. Use Caution/Monitor.epinephrine and levalbuterol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Effect of interaction is not clear, use caution. Effect of interaction is not clear, use caution. Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. [56], Little further work was done with thalidomide in cancer until the 1990s. [66] The FDA subsequently initiated the Drug Efficacy Study Implementation to reclassify drugs already on the market. Use Caution/Monitor. Combination may increase CNS stimulatory effects due to caffeine in green tea. If coadministered, monitor for changes in heart rate, heart rhythm, and blood pressure. Monitor Closely (4)dopexamine, epinephrine. Carbamazepine has effects on serotonin systems but the relevance to its antiseizure effects is uncertain. Monitor Closely (1)phenobarbital increases and epinephrine decreases sedation. Both drugs can cause metabolic acidosis. Modify Therapy/Monitor Closely. encoded search term (epinephrine (EpiPen%2C Auvi-Q)) and epinephrine (EpiPen, Auvi-Q), Is There a Doctor on the Plane? Use Caution/Monitor. Monitor Closely (1)thiothixene increases and epinephrine decreases sedation. cabergoline, epinephrine. Use an Auto-Injector only one time. Block pressor response to epinephrine, which may result in severe hypotension and tachycardia. loxapine increases and epinephrine decreases sedation. Monitor Closely (1)phenoxybenzamine, epinephrine. Use Caution/Monitor. Effect of interaction is not clear, use caution. There is also a risk of anemia via lack of red blood cells. Effect of interaction is not clear, use caution. It is used as an adjunctive treatment in schizophrenia along with other medications and as a second-line agent in bipolar disorder. Effect of interaction is not clear, use caution. Block pressor response to epinephrine, which may result in severe hypotension and tachycardia. Use Caution/Monitor. WebProp 30 is supported by a coalition including CalFire Firefighters, the American Lung Association, environmental organizations, electrical workers and businesses that want to improve Californias air quality by fighting and preventing epinephrine and bumetanide both decrease serum potassium. Strong alpha-adrenergic effects, which cause an increase in cardio output and HR, a decrease in renal perfusion and PVR, and a variable effect on BP, resulting in systemic vasoconstriction and increased vascular permeability, Strong beta1- and moderate beta2-adrenergic effects, resulting in bronchial smooth muscle relaxation, Secondary relaxation effect on smooth muscle of stomach, intestine, uterus, and urinary bladder, Metabolized by MAO and COMT in adrenergic neuron, Metabolites: Metadrenaline, sulfate conjugates, and hydroxy derivatives of mandelic acid (inactive), Solution: Na-bicarbonate 5%, Ionosol PSL, Ionosol T/D5, Additive: Aminophylline, hyaluronidase, mephentermine, Na-bicarbonate, Not specified: Atropine, carbenicillin, diazepam, erythromycin, lidocaine, Solution: D5W, D10W, dextrose-Ringer's, dextrose-saline, NS, LR, Ringer's, Additive: Amikacin, cimetidine, dobutamine, floxacillin, furosemide, metaraminol, ranitidine, verapamil, Syringe: Caffeine, doxapram, heparin, milrinone, Y-site: Amiodarone, atracurium, bivalirudin, CaCl2, Ca gluconate, cefpirome, cisatracurium, dexmedetomidine, diltiazem, dobutamine, dopamine, famotidine, fenoldopam, fentanyl, furosemide, heparin, Hextend, hydrocortisone Na succinate, hydromorphone, inamrinone, labetalol, levofloxacin, lorazepam, midazolam, milrinone, morphine SO4, nicardipine, nitroglycerin, norepinephrine, pancuronium, phytonadione, KCl, propofol, ranitidine, remifentanil, nitroprusside, tirofiban, vasopressin, vecuronium, vitamin B/C, warfarin, Dilute epinephrine in D5W or D5W 0.9% NaCl, Administration in saline solution alone is not recommended, Add 1 mL (1 mg) of epinephrine from its ampule to 1000 mL of a D5W containing solution, Each mL of this dilution contains 1 mcg of epinephrine, Solution: 1 mg in 250 mL D5W or NS (4 mcg/mL) to make up concentration of 15-60 mL/hr (1-4 mcg/min), Correct blood volume depletion as fully as possible prior to administering any vasopressor, When, as an emergency measure, intraaortic pressures must be maintained to prevent cerebral or coronary artery ischemia, epinephrine can be administered before and concurrently with blood volume replacement, Whenever possible, administer epinephrine infusions into a large vein, Avoid using a catheter tie-in technique, because the obstruction to blood flow around the tubing may cause stasis and increased local concentration of the drug, Discard after 24 hours or if solution is discolored or contains precipitate, Epinephrine must be diluted prior to intraocular use, Dilute 1 mL of epinephrine 1 mg/mL (1:1000) in 100 to 1000 mL of an ophthalmic irrigation fluid to create an epinephrine concentration of 1:100,000 to 1:1,000,000 (10-1 mcg/mL), Use the irrigating solution as needed for the surgical procedure, After dilution in an ophthalmic irrigating fluid, inject intracamerally, Inject IM or SC into the anterolateral aspect of the thigh, through clothing if necessary, Do not administer autoinjector IV; administer only in outer thigh to ensure SC or IM administration, Do not inject into buttock, or into digits, hands, or feet, To minimize the risk of injection-related injury, instruct caregivers to hold the child's leg firmly in place and limit movement prior to and during injection when administering to young children, Discard remaining volume after dose has been administered, In conjunction with use, seek immediate medical or hospital care, COMMON BRAND NAME(S): Auvi-Q, Epipen, Symjepi, Twinject. Monitor Closely (1)clonazepam increases and epinephrine decreases sedation. Avoid or Use Alternate Drug. Use Caution/Monitor. Avoid or Use Alternate Drug. The most common side effect of replacement digestive enzymes is constipation. Monitor Closely (1)brompheniramine increases and epinephrine decreases sedation. View the formulary and any restrictions for each plan. Effect of interaction is not clear, use caution. Use Caution/Monitor.epinephrine and dexfenfluramine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely. Other less common symptoms may include: nausea; abdominal cramps; diarrhea Effect of interaction is not clear, use caution. Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. 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